https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Prognostic role of metabolic parameters of ¹⁸F-FDG PET-CT scan performed during radiation therapy in locally advanced head and neck squamous cell carcinoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28291 max), metabolic tumour volume (MTV) and total lesional glycolysis (TLG) of primary tumour (PT) and index node (IN) [defined as lymph node(s) with highest TLG] were analysed, and results were correlated with loco-regional recurrence-free survival (LRFS), disease-free survival (DFS), metastatic failure-free survival(MFFS) and overall survival (OS), using Kaplan-Meier analysis. Results: Optimal cutoffs (OC) were derived from receiver operating characteristic curves: SUVmax-PT=4.25 g/mL, MTVPT=3.3 cm³, TLGPT=9.4 g, for PT, and SUVmax-IN=4.05 g/mL, MTVIN=1.85 cm³ and TLGIN=7.95 g for IN. Low metabolic values in iPET for PT below OC were associated with statistically significant better LRFS and DFS. TLG was the best predictor of outcome with 2-year LRFS of 92.7 % vs. 71.1% [p=0.005, compared with SUVmax (p=0.03) and MTV (p=0.022)], DFS of 85.9% vs. 60.8% [p=0.005, compared with SUVmax (p=0.025) and MTV (p=0.018)], MFFS of 85.9% vs. 83.7% [p=0.488, compared with SUVmax (p=0.52) and MTV (p=0.436)], and OS of 81.1% vs. 75.0% [p=0.279, compared with SUVmax (p=0.345) and MTV (p=0.512)]. There were no significant associations between the percentage reduction of primary tumour metabolic parameters and outcomes. In patients with nodal disease, metabolic parameters below OC (for both PT and IN) were significantly associated with all oncological outcomes, while TLG was again the best predictor: LRFS of 84.0% vs. 55.3% (p=0.017), DFS of 79.4% vs. 38.6% (p=0.001), MFFS 86.4% vs. 68.2% (p=0.034) and OS 80.4% vs. 55.7% (p=0.045). Conclusion: The metabolic parameters of iPET can be useful predictors of patient outcome and potentially have a role in adaptive therapy for MPHNSCC. Among the three parameters, TLG was found to be the best prognostic indicator of oncological outcomes.]]> Wed 11 Apr 2018 10:09:13 AEST ]]> Gastrostomy dependency trends over 15 years of patients at a large tertiary referral center following the insertion of a prophylactic gastrostomy for chemoradiation for mucosal head and neck cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41425 Wed 03 Aug 2022 12:06:20 AEST ]]> 18F-FDG PET-CT performed before and during radiation therapy of head and neck squamous cell carcinoma: are they independent or complementary to each other? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29991 18F-FDG PET-CT performed before definitive radiation therapy (RT) (prePET) in patients with mucosal primary head and neck squamous cell carcinoma (MPHNSCC) and to assess the additive prognostic values of FDG PET-CT performed during RT (iPET). Methods: One hundred patients with MPHNSCC treated with radical RT underwent staging prePET and iPET performed during the third week of treatment. The maximum standardized uptake value (SUVmax), metabolic tumour volume (MTV) and total lesional glycolysis (TLG) of primary tumour were analysed for both prePET and iPET, and results were correlated with loco-regional recurrence-free survival (LRFS), disease-free survival (DFS), metastatic failure-free survival (MFFS) and overall survival (OS), using Kaplan–Meier analysis. Optimal cut-offs (OC) for prePET and iPET were derived from Receiver Operating Characteristic curves. Patients with metabolic parameters above/below the individual OC of prePET as well as iPET (i.e. combined prePET and iPET (comPET)) were evaluated against their outcomes. Results: Median age was 61 years (range 39–81), median follow-up of 20 months (range 4–70, mean 27), and AJCC 7th Edition clinical stage II, III and IV were 8, 24 and 68 patients respectively. Metabolic values below individual OC in comPET were found to be associated with statistically significant improvements (P < 0.05) in DFS, LRFS and OS. In addition, patients with SUVmax above the OC in comPET were associated with worse MFFS (P = 0.011) and confirmed on both univariate (P = 0.019) and multivariate analyses (P = 0.04). Conclusion: Addition of iPET significantly improves the prognostic values of all three metabolic parameters and can potentially be used in future adaptive local and systemic therapy trials.]]> Thu 28 Oct 2021 12:36:43 AEDT ]]> Situational anxiety in head and neck cancer: Rates, patterns and clinical management interventions in a regional cancer setting https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54915 Thu 21 Mar 2024 12:02:51 AEDT ]]> Assessing the impact of magnetic resonance treatment simulation (MRSIM) on target volume delineation and dose to organs at risk for oropharyngeal radiotherapy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46836 Thu 01 Dec 2022 15:01:24 AEDT ]]> Oncology and radiation oncology awareness in final year medical students in Australia and New Zealand https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46205 Mon 14 Nov 2022 11:29:52 AEDT ]]> Junior Doctor Evaluation of Radiation Oncology Education and Training in Medical Schools and Prevocational Training in Australia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44209 Mon 10 Oct 2022 15:49:45 AEDT ]]> The status of radiation oncology teaching in Australian and New Zealand medical schools https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41774 Fri 12 Aug 2022 11:56:45 AEST ]]>